Whisk buttermilk, salt, and pepper in a bowl. Add the chicken pieces and allow them to tenderize for 15 minutes (making sure they are fully covered in the buttermilk).
Combine the all-purpose flour, paprika, garlic powder, and onion powder in a shallow dish.
Preheat the oven to 375°F (190°C).
Remove the chicken pieces from the buttermilk and pat them dry with a clean paper towel.
Roll each drumstick in the seasoned flour mixture, pressing the flour onto the chicken to create a thick coating.
Spray a wire rack with cooking spray and set it on a baking sheet.
Place the coated chicken on the wire rack, spaced at least 3” apart.
Bake 40 minutes, flipping halfway through until they reach 165°F and are browned and crispy on the outside. Let fried chicken rest 5 minutes before serving.